Mechanistic Insights into the Anti-angiogenic Activity of Trypanosoma cruzi Protein 21 and its Potential Impact on the Onset of Chagasic Cardiomyopathy.

作者： Samuel Cota Teixeira , Daiana Silva Lopes , Sarah Natalie Cirilo Gimenes , Thaise Lara Teixeira , Marcelo Santos da Silva

DOI: 10.1038/SREP44978

关键词:

摘要: Chronic chagasic cardiomyopathy (CCC) is arguably the most important form of Chagas Disease, caused by intracellular protozoan Trypanosoma cruzi; it estimated that 10-30% chronic patients develop this clinical manifestation. The common and severe CCC can be related to ventricular abnormalities, such as heart failure, arrhythmias, blocks, thromboembolic events sudden death. Therefore, in study, we proposed evaluate anti-angiogenic activity a recombinant protein from T. cruzi named P21 (rP21) potential impact native on CCC. Our data suggest rP21 depends protein's direct interaction with CXCR4 receptor. This capacity likely modulation expression actin angiogenesis-associated genes. Thus, our results indicate an attractive target for development innovative therapeutic agents against

参考文章(87)

M. A. Rossi, J. S. Silva, Intensification of acute Trypanosoma cruzi myocarditis in BALB/c mice pretreated with low doses of cyclophosphamide or gamma irradiation. Experimental pathology. ,vol. 71, pp. 33- 39 ,(1990)

Jill A Macoska, Lesa A Begley, Sathish Kasina, Rajal B Shah, Signaling mechanisms coupled to CXCL12/CXCR4-mediated cellular proliferation are PTEN-dependent. American journal of clinical and experimental urology. ,vol. 3, pp. 91- 99 ,(2015)

F Bussolino, F Colotta, E Bocchietto, A Bosia, E DeJana, A Sica, I M Padura, A Mantovani, M De Rossi, J M Wang, Murine endothelioma cell lines transformed by polyoma middle T oncogene as target for and producers of cytokines. Journal of Immunology. ,vol. 147, pp. 2122- 2129 ,(1991)

Shigeyoshi Itohara, Masatoshi Tanioka, Hiroshi Yoshida, Hirofumi Nishimoto, Takeshi Itoh, Takayuki Yoshioka, Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Research. ,vol. 58, pp. 1048- 1051 ,(1998)

Hideki Amano, Shintaro Kato, Yoshiya Ito, Koji Eshima, Fumihiro Ogawa, Ryo Takahashi, Kazuki Sekiguchi, Hideaki Tamaki, Hiroyuki Sakagami, Masabumi Shibuya, Masataka Majima, The Role of Vascular Endothelial Growth Factor Receptor-1 Signaling in the Recovery from Ischemia PLOS ONE. ,vol. 10, pp. e0131445- ,(2015) , 10.1371/JOURNAL.PONE.0131445

Eleanna Stamatakou, Monica Hoyos-Flight, Patricia C. Salinas, Wnt Signalling Promotes Actin Dynamics during Axon Remodelling through the Actin-Binding Protein Eps8 PLOS ONE. ,vol. 10, pp. e0134976- ,(2015) , 10.1371/JOURNAL.PONE.0134976

Z. Zhou, S. S. Apte, R. Soininen, R. Cao, G. Y. Baaklini, R. W. Rauser, J. Wang, Y. Cao, K. Tryggvason, Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 4052- 4057 ,(2000) , 10.1073/PNAS.060037197

R. J. Pelham, Y.-l. Wang, Cell locomotion and focal adhesions are regulated by substrate flexibility Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 13661- 13665 ,(1997) , 10.1073/PNAS.94.25.13661

Frank W. Torres, Harry Acquatella, Jose A. Condado, Robert Dinsmore, Igor F. Palacios, Coronary vascular reactivity is abnormal in patients with Chagas' heart disease. American Heart Journal. ,vol. 129, pp. 995- 1001 ,(1995) , 10.1016/0002-8703(95)90122-1

10.

Mahmut Yilmaz, Gerhard Christofori, EMT, the cytoskeleton, and cancer cell invasion Cancer and Metastasis Reviews. ,vol. 28, pp. 15- 33 ,(2009) , 10.1007/S10555-008-9169-0

Mechanistic Insights into the Anti-angiogenic Activity of Trypanosoma cruzi Protein 21 and its Potential Impact on the Onset of Chagasic Cardiomyopathy.

来源期刊

我的账户

Mechanistic Insights into the Anti-angiogenic Activity of Trypanosoma cruzi Protein 21 and its Potential Impact on the Onset of Chagasic Cardiomyopathy.

来源期刊

相似文章 9

我的账户