The Lack of the Bronchoprotective and Not the Bronchodilatory Ability of Deep Inspiration Is Associated with Airway Hyperresponsiveness

摘要: In healthy subjects, deep inspiration (DI) acts both as a bronchodilator and bronchoprotector. The latter is impaired in asthmatics. We have now evaluated whether the lack of bronchoprotection related to bronchial hyperresponsiveness (BHR), bronchodilatory effect also lost Ten subjects (PC20 > 75 mg/ml), 12 asthmatics with moderate severe BHR < 1 14 mild borderline (1 PC20 25 10 rhinitics mg/ml) underwent single-dose methacholine provocations inducing at least 20% reduction FEV1 after 20 min DI inhibition. To measure effect, DIs were taken immediately postmethacholine spirometry, lung function was again tested. bronchoprotective before administration spasmogen. All four groups achieved same reductions FVC, absence breaths (analysis variance [ANO...