Central Nervous System Stimulants: Neuropharmacological Mechanisms

摘要: The mechanisms underlying CNS-stimulant drug discrimination are discussed. Although different doses of CNS stimulants may produce qualitatively cues, it appears that a relatively low dose d-amphetamine (e.g., 1 mg/kg) elicits “general” cue. Presynaptically, this cue primarily depend on release endogeneous dopamine whereas inhibition reuptake, per se, is insufficient to elicit the Postsynaptically, involvement both D-1 and D-2 receptors implicated. Furthermore, in situation, D-1/D-2 be coupled differently than dopamine-dependent locomotor activation. Anatomically, mesolimbic systems.