Cerebrospinal fluid apolipoprotein E is reduced in Alzheimer's disease.

摘要: Apolipoprotein E (ApoE) has been implicated in the pathogenesis of Alzheimer's disease (AD). ApoE is synthesized within brain and suggested to be involved re-utilization membrane lipids during neuronal repair remyelination after injury. Spherical ApoE-containing lipoprotein particles are found cerebrospinal fluid (CSF). To study further pathogenetic role degenerative disorders, we analysed CSF. A significant (p < 0.001) reduction CSF (1.5 +/- 1.2 ng ml-1) was AD compared with controls (5.0 2.7 ml-1). less pronounced also frontal lobe dementia (3.1 1.5 ml-1; p 0.05). These findings support hypothesis that disorders such as AD. An increased reutilization ApoE-lipid complexes brain, part a generalized process, may explain low Alternatively, caused by absorption senile plaques neurofibrillary tangles.