Cerebrospinal fluid markers for Alzheimer's disease evaluated after acute ischemic stroke.
作者： Camilla Hesse , Lars Rosengren , Eugeen Vanmechelen , Hugo Vanderstichele , Christer Jensen
关键词: Apolipoprotein E 、 Tau protein 、 Cerebrospinal fluid 、 Disease 、 Acute ischemic stroke 、 Internal medicine 、 Pathology 、 Amyloid beta 、 Beta (finance) 、 Medicine 、 Gastroenterology 、 Stroke
摘要: Abstract Potential cerebrospinal fluid (CSF) markers for Alzheimer's disease (AD) include tau protein, the 42 amino-acid form of amyloid beta (amyloid beta(1-42)) and apolipoprotein E (apoE). To study new aspects these protein markers, we examined consecutive CSF samples from 26 patients with acute ischemic stroke. were taken on day 0-1, 2-3, 7-9, 3 weeks 3-5 months after CSF-tau showed a marked increase which peaked 1 week returned to normal months. also correlation (r=0.95; p<0.01) size infarct. In contrast, CSF-amyloid beta(1-42) CSF-apoE no significant changes during period. The in levels stroke indicate that reflect degree neuronal damage. reason unchanged remains unclear.
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