Chapter 12 – Computational Epigenetics

摘要: Epigenetics has emerged as a rapidly growing field for studying the heritable alterations involved in regulation of gene expression patterns that are not due to changes DNA sequence. To which, epigenetic mechanisms, such methylation and histone modifications, can modulate chromatin structure regulation, during cellular development differentiation higher organisms. Recent advancements high-throughput profiling technologies, including bisulfite microarray, sequencing, affinity enrichment, ChIP-on-chip, ChIP have generated vast amounts epigenomic data. In turn, developments bioinformatics databases software tools thus contributed significantly substantial, growing, interest research. This chapter reviews key aspects techniques computational epigenetics. particular, major tools, databases, strategies epigenetics analysis modifications been summarized.