dbHiMo: a web-based epigenomics platform for histone-modifying enzymes.
作者： J. Choi , K.-T. Kim , A. Huh , S. Kwon , C. Hong
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摘要: Over the past two decades, epigenetics has evolved into a key concept for understanding regulation of gene expression. Among many epigenetic mechanisms, covalent modifications such as acetylation and methylation lysine residues on core histones emerged major mechanism in regulation. Here, we present database histone-modifying enzymes (dbHiMo; http://hme.riceblast.snu.ac.kr/) aimed at facilitating functional comparative analysis (HMEs). HMEs were identified by applying search pipeline built upon profile hidden Markov model (HMM) to proteomes. The incorporates 11,576 from 603 proteomes including 483 fungal, 32 plants 51 metazoan species. dbHiMo provides users with web-based personalized data browsing tools, supporting evolutionary genomics. With comprehensive entries associated our will be valuable resource future epigenetics/epigenomics studies.
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