Benchmarking and validation of a Geant4-SHADOW Monte Carlo simulation for dose calculations in microbeam radiation therapy.
作者： Iwan Cornelius , Susanna Guatelli , Pauline Fournier , Jeffrey C. Crosbie , Manuel Sanchez del Rio
DOI: 10.1107/S1600577514004640
关键词:
摘要: Microbeam radiation therapy (MRT) is a synchrotron-based radiotherapy modality that uses high-intensity beams of spatially fractionated to treat tumours. The rapid evolution MRT towards clinical trials demands accurate treatment planning systems (TPS), as well independent tools for the verification TPS calculated dose distributions in order ensure patient safety and efficacy. Monte Carlo computer simulation represents most method calculation geometries best suited purpose verification. A model ID17 biomedical beamline at European Synchrotron Radiation Facility has been developed, including recent modifications, using Geant4 toolkit interfaced with SHADOW X-ray optics ray-tracing libraries. code was benchmarked by simulating profiles water-equivalent phantoms subject irradiation broad-beam (without spatial fractionation) microbeam (with fields, comparing against those previous developed PENELOPE code. Validation additional experimental also performed. Good agreement between codes observed, exception out-of-field doses toward field edge larger sizes. results showed good both within uncertainties. Results validation different configurations. asymmetry due polarization effects investigated, yielding important information process MRT. This work an step development Carlo-based tool
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