Origin and dispersal of Hepatitis E virus.

摘要: Hepatitis E virus (HEV, genus Orthohepevirus) is a common cause of hepatitis worldwide. Human-infecting HEV strains (Orthohepevirus A) include human-restricted and enzootic genotypes. Viruses in the Orthohepevirus A species also infect rabbits (HEV-3ra), camels, swine. Using selection-informed method, we dated origin at least 21 million years ago, whereas originated Asia, most likely from human-infecting ancestor that existed ~4500 to 6800 ago. In this period, appearance large human settlements probably facilitated emergence spread. The earliest events evolutionary history involved separation genotypes, as well split camel-infecting which occurred during time-frame camel domestication. place timing HEV-3ra divergence correspond circumstances rabbit This study clarifies historical underlying dispersal.