Inhibition of alkaline phosphatase activity of boar semen by pentoxifylline, caffeine, and theophylline.
作者： Jan Glogowski , Andrzej Ciereszko , Douglas R. Danforth
DOI: 10.1002/J.1939-4640.2002.TB02334.X
关键词:
摘要: Methyl xanthines have been used frequently as additives to sperm suspensions in order improve characteristics. The mechanism of action on spermatozoa is generally assumed be inhibition phosphodiesterase activity, resulting elevation complementary adenosine monophosphate levels spermatozoa. present study was designed examine the effect methyl (pentoxifylline, caffeine, and theophylline) another important enzyme system, alkaline phosphatase, boar seminal plasma Inhibition phosphatase could distinguished from that by a paradoxical stimulation pentoxifylline at lower pH values Among three xanthines, theophylline exhibited most dramatic activity substrate observed with increasing concentrations. Each xanthine had different pH; showed highest inhibition, caffeine not related pH, did inhibit and, fact, it stimulated its (or optimum) These results indicate possible are agreement data indicating specific inhibitors phosphodiesterase, because clearly, they well.
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