Treating cancer with heat: hyperthermia as promising strategy to enhance apoptosis.

摘要: The fundamental idea and the effects of heat on cancer cells are well known. However, results obtained in therapy by hyperthermia (HT) alone have been only partially satisfactory. Treatment at temperatures between .40 44 degrees C is cytotoxic for an environment with a low oxygen partial pressure pH, conditions that found specifically within tumour tissue, due to insufficient blood perfusion. Under such radiotherapy less effective, systemically applied agents will reach areas lower concentrations than well-perfused areas. Therefore, clinically, it preferred use combination radiation chemotherapy. Hyperthermia can be several methods: local external or internal energy sources; regional perfusion organs limbs, irrigation body cavities; whole-body hyperthermia. Number studies reported thermo-radiotherapy. Consequently, much attention has focussed identifying among conventional chemotherapeutic substances sensitise hyperthermia-induced damage minimal normal cells. In this review, we overviewed important mechanisms apoptosis which act as sensitisers therapy.