CSF somatostatin increase in patients with early parkinsonian syndrome

摘要: Somatostatin-like immunoreactivity levels (SLI) in cerebrospinal fluid (CSF) were determined twenty-three patients with untreated parkinsonian syndrome (15 Idiopathic Parkinson's disease (IPD) and 8 other forms of parkinsonism) at the moment clinical diagnosis (mean duration 1.1±0.2 years), 26 subjects without neurological symptoms. None IPD had a dementia inclusion study. CSF-SLI content was found to be significantly higher (107.9±9.8 pg/ml) than control (73.5±8.4 pg/ml). The increase also significant when controls compared patients. In addition, positive correlation between SLI homovanillic acid CSF all A test learning memory used evaluate mental state CSF-somatostatin observed severe affectation memory. These results indicate that early steps syndrome, somatostatin concentration may increase, probably due neurodegenerative depletion from striatal or cortical neurons.