Evaluation of biomarkers following autologous osteochondral transplantation in the equine stifle joint - An experimental study.

摘要: The purpose of this study was to evaluate changes in biomarker and synovial parameters following autologous osteochondral transplantation (AOT) the equine stifle joint, test hypothesis whether would show significant differences at selected time points surgery (at days 3, 14, 60 180) compared baseline level day 0). Surgical intervention performed both stifles nine horses (n = 18). joints were randomly assigned operated sham-operated groups. Grafts 8.5 mm diameter harvested from femoropatellar (FP) joint under arthroscopic control medial femorotibial (MFT) had AOT using mosaicplasty (MP) instrumentation, while sham FP MFT underwent arthroscopy miniarthrotomy without transplantation, respectively. Synovial fluid (SF) evaluated 4, 180. Data analysed by two-way repeated- measures analysis variance (ANOVA), P < 0.05 considered significant. During first 10-14 after surgery, lameness degree 2-3/5 [American Association Equine Practitioners (AAEP) scores] present, which disappeared days. Joints with showed increases white blood cell count (WBC), total protein (TP), substance P, C1,2C CS846 epitope concentration 3 shamoperated (P 0.05). These returned values two months remained within normal levels 6 postoperatively.