Strategies in developing interfaces for coupling liquid chromatography and mass spectrometry

摘要: Abstract Considerable progress has been made over the last 20 years in coupling liquid chromatography and mass spectrometry. A large number of interfaces have developed and, although only a few found widespread application, developments interfacing are worth reviewing. The categorized along three lines: efforts to introduce 1 ml/min an aqueous mobile phase into spectrometer vacuum system, achieve analyte enrichment interface combine liquid-based soft ionization techniques. These lines explored, with special attention being given most successful interfaces. Some similarities between various revealed.