The Structural Development of the Mouse Dorsal Cochlear Nucleus

摘要: The dorsal cochlear nucleus (DCN) is a major subdivision of the mammalian (CN) that thought to be involved in sound localization vertical plane and feature extraction stimuli. main principal cell type (pyramidal cells) integrates auditory non-auditory inputs, which are considered important performing tasks. This study aimed investigate histological development CD-1 mouse DCN, focussing on postnatal period spanning onset hearing (P12). Fluorescent Nissl staining revealed three layers DCN were identifiable as early P6 with subsequent expansion all age. Significant increases size pyramidal cartwheel cells observed between birth P12. Immunohistochemistry showed substantial changes synaptic distribution during first two weeks maturation presumed mossy fibre terminals. In addition, GFAP immunolabelling identified several glial types including observation putative tanycytes for time. Each had specific spatial temporal patterns apparent rapid but little change thereafter. structural organization components prior possibly reflects an influence from spontaneous activity originating cochlea/auditory nerve. Further refinement these connections may result arrival acoustic input experience dependent mechanisms.