Borne Identity: Leading Endogenous Suspects at Imidazoline Binding Sites

摘要: Over the past few years, a vast amount of research has shed light on pharmacology imidazoline binding sites (I-BS). To date, at least three classes have been characterised in accordance to their localisation, drug selectivity, proposed signalling pathways and functional roles. The existence these raises question as whether an endogenous modulator exists. identification extract denoted clonidine displacing substance prompted search for active ingredient capable mimicking action selective ligands sites. A number candidates isolated activities assessed Such include agmatine, imidazoleacetic acid ribotide β-carboline harmane. As yet, no consensus made confirm identity ligand I-BS. current review collates reports what is known about substances significance