Effect of postmortem delay on imidazoline receptor-binding proteins in human and mouse brain.

摘要: Immunoreactive proteins of 45-kD and 29/30-kD doublet bands are candidate imidazoline receptor binding (IRBP) based on associations with I(1) or I(2) sites, respectively. It was reported that the density cortical membrane protein is diminished whereas a increased in depressed suicide victims versus controls. IRBP immunoreactive similar size have been suggested to be breakdown products 170-kD known as IRAS (putative full-length receptor). This study compares nonpathologic human brains collected frozen after postmortem delays 13.4 hours +/- 1.7 (SEM) longer (26.1 1.2). The fresher possessed more (P = 0.05). In another study, decay mouse brain shown linear over time. results relevant previous studies victims.