FLAIR signal increase of the fluid within the resection cavity after glioma surgery: generally valid as early recurrence marker?

摘要: OBJECTIVE Recent studies have indicated that a signal intensity increase of the fluid within resection cavity on FLAIR images may predict tumor recurrence after glioma surgery. The aim this study was to assess in large patient cohort and subgroups its prognostic value for early patients. METHODS A total 212 patients (213 cases) who had undergone surgery an intracranial (WHO Grade IV [n = 103], WHO III 57], II 53]) were included retrospective study. at time recurrence/last contact previous MRI assessed qualitatively quantitatively. Appearance studied over using Kaplan-Meier estimates subgroups. RESULTS Patients with connection CSF did not undergo radiotherapy regularly develop sign excluded from further analysis. For remaining 87 cases, observed 27 cases. Recurrent disease found 26 these resulting specificity 80.0%, sensitivity 31.7%, positive negative predictive values 96.3% 6.7%, respectively. In 4 cases been prior (range 2.8-8.5 months) defined by standard criteria. Quantitative analysis underlined results qualitative analysis, but it add diagnostic value. CONCLUSIONS Signal is rare highly specific recurrence/tumor progression completely incompletely resected high-grade without radiotherapy.