Optimal role of temozolomide in the treatment of malignant gliomas.
作者： Roger Stupp , Martin J. van den Bent , Monika E. Hegi
DOI: 10.1007/S11910-005-0047-7
关键词:
摘要: Temozolomide (TMZ) is an alkylating agent that was approved for anaplastic astrocytoma and glioblastoma. Its role in the treatment of recurrent disease has been confirmed, more importantly, alternative schedules combination regimens have developed. A recent phase III trial demonstrated a survival advantage concomitant TMZ administration with radiotherapy patients newly diagnosed Molecular studies suggest strong predictive DNA repair enzyme O6-methyl-guanine-DNA-methyl-transferase (MGMT) outcome TMZ-based chemotherapy. This review summarizes current knowledge, highlights nonapproved indications, describes molecular may allow us to identify most likely benefit from this treatment.
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F. Anthony Greco, John D. Hainsworth, Suzanne F. Jones, Howard A. Burris, Dianna L. Shipley, Victor G. Gian, Fernando T. Miranda, Dana S. Thompson, Mitchell A. Toomey, Noel T. Willcutt, Phase I. Trial of irinotecan and temozolomide in patients with solid tumors. Oncology. ,vol. 17, pp. 41- 45 ,(2003)
Anuj K. Mahindra, Stuart A. Grossman, Pneumocystis carinii pneumonia in HIV negative patients with primary brain tumors. Journal of Neuro-oncology. ,vol. 63, pp. 263- 270 ,(2003) , 10.1023/A:1024217527650
Susan M Chang, Michael D Prados, WK Alfred Yung, Howard Fine, Larry Junck, Harry Greenberg, H Ian Robins, Minesh Mehta, Karen L Fink, Kurt A Jaeckle, John Kuhn, Kenneth Hess, Clifford Schold, None, Phase II study of neoadjuvant 1, 3-bis (2-chloroethyl)-1-nitrosourea and temozolomide for newly diagnosed anaplastic glioma: a North American Brain Tumor Consortium Trial. Cancer. ,vol. 100, pp. 1712- 1716 ,(2004) , 10.1002/CNCR.20157
Oliver-Louis Chinot, Stephane Honore, Henry Dufour, Maryline Barrie, Dominique Figarella-Branger, Xavier Muracciole, Diane Braguer, Pierre-Marie Martin, François Grisoli, None, Safety and Efficacy of Temozolomide in Patients With Recurrent Anaplastic Oligodendrogliomas After Standard Radiotherapy and Chemotherapy Journal of Clinical Oncology. ,vol. 19, pp. 2449- 2455 ,(2001) , 10.1200/JCO.2001.19.9.2449
Eric T. Wong, Kenneth R. Hess, Mary Jo Gleason, Kurt A. Jaeckle, Athanassios P. Kyritsis, Michael D. Prados, Victor A. Levin, W.K. Alfred Yung, Outcomes and Prognostic Factors in Recurrent Glioma Patients Enrolled Onto Phase II Clinical Trials Journal of Clinical Oncology. ,vol. 17, pp. 2572- 2578 ,(1999) , 10.1200/JCO.1999.17.8.2572
H S Friedman, D M Kokkinakis, J Pluda, A H Friedman, I Cokgor, M M Haglund, D M Ashley, J Rich, M E Dolan, A E Pegg, R C Moschel, R E McLendon, T Kerby, J E Herndon, D D Bigner, S C Schold, Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma Journal of Clinical Oncology. ,vol. 16, pp. 3570- 3575 ,(1998) , 10.1200/JCO.1998.16.11.3570
Henry S. Friedman, William P. Petros, Allan H. Friedman, Larry J. Schaaf, Tracy Kerby, Jennifer Lawyer, Mary Parry, Peter J. Houghton, Shelley Lovell, Karima Rasheed, Tim Cloughsey, Elizabeth S. Stewart, O. Michael Colvin, James M. Provenzale, Roger E. McLendon, Darell D. Bigner, Ilkcan Cokgor, Michael Haglund, Jeremy Rich, David Ashley, Joseph Malczyn, Gary L. Elfring, Langdon L. Miller, Irinotecan Therapy in Adults With Recurrent or Progressive Malignant Glioma Journal of Clinical Oncology. ,vol. 17, pp. 1516- 1525 ,(1999) , 10.1200/JCO.1999.17.5.1516
K A Jaeckle, H J Eyre, J J Townsend, S Schulman, H M Knudson, M Belanich, D B Yarosh, S I Bearman, D J Giroux, S C Schold, Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis- chloroethylnitrosourea: a Southwest Oncology Group study Journal of Clinical Oncology. ,vol. 16, pp. 3310- 3315 ,(1998) , 10.1200/JCO.1998.16.10.3310
H S Friedman, R E McLendon, T Kerby, M Dugan, S H Bigner, A J Henry, D M Ashley, J Krischer, S Lovell, K Rasheed, F Marchev, A J Seman, I Cokgor, J Rich, E Stewart, O M Colvin, J M Provenzale, D D Bigner, M M Haglund, A H Friedman, P L Modrich, DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma. Journal of Clinical Oncology. ,vol. 16, pp. 3851- 3857 ,(1998) , 10.1200/JCO.1998.16.12.3851
D R Macdonald, T L Cascino, S C Schold, J G Cairncross, Response criteria for phase II studies of supratentorial malignant glioma. Journal of Clinical Oncology. ,vol. 8, pp. 1277- 1280 ,(1990) , 10.1200/JCO.1990.8.7.1277