A Prospective Multicenter Study of Hepatocellular Carcinoma in Italian Hemophiliacs With Chronic Hepatitis C

摘要: To assess the risk factors, natural history, and eligibility for curative treatment of early-detected hepatocellular carcinoma (HCC), 385 hemophiliacs who were treated with blood or plasma derivates at least 10 years had persistently elevated aminotransferase values underwent an annual screening abdominal ultrasound examination measurement serum alpha-fetoprotein (AFP) level. Of these, 355 antibody to hepatitis C virus (anti-HCV), 29 anti-HCV B surface antigen (HBsAg), one HBsAg alone; 141 human immunodeficiency (anti-HIV). During 48 months follow-up study, six patients developed HCC. All HCC a HCV-related cirrhosis been exposed HCV median age 40 years. multicentric tumor, which was not eligible treatment. Univariate analysis showed age, cirrhosis, baseline AFP levels be significantly associated increased By multivariate analysis, infinite in 31.0 those higher than 11 ng/mL, 17.9 more 45 age. In conclusion, cancer greater infected later life, particularly high AFP. Annual fails identify potentially curable tumors because diagnosis is made late stage disease.