Biomedical informatics: development of a comprehensive data warehouse for clinical and genomic breast cancer research
作者： Hai Hu , Henry Brzeski , Joe Hutchins , Mohan Ramaraj , Long Qu
关键词:
摘要: The Windber Research Institute is an integrated high-throughput research center employing clinical, genomic and proteomic platforms to produce terabyte levels of data. We use biomedical informatics technologies integrate all these operations. This report includes information on a multi-year, multi-phase hybrid data warehouse project currently under development in the Institute. purpose host terabyte-level internal experimentally generated as well from public sources. have previously reported phase I development, which limited sources selected databases. Currently, we are completing II integrates our automated develops visualization tools query across types. paper summarizes clinical experimental operations, challenges faced. In III plan federate additional manual ...
futuremedicine.com
sci-hub.se 参考文章(13)
Ralph Kimball, The data warehouse toolkit: practical techniques for building dimensional data warehouses John Wiley & Sons, Inc.. ,(1996)
Gene Ontology Consortium, None, The Gene Ontology (GO) database and informatics resource Nucleic Acids Research. ,vol. 32, pp. 258D- 261 ,(2004) , 10.1093/NAR/GKH036
D.L. Ellsworth, C.D. Shriver, R.E. Ellsworth, B. Deyarmin, R.I. Somiari, Laser capture microdissection of paraffin-embedded tissues. BioTechniques. ,vol. 34, pp. 42- 46 ,(2003) , 10.2144/03341BM05
Stella B. Somiari, Craig D. Shriver, Jing He, Kishan Parikh, Rick Jordan, Jeffrey Hooke, Hai Hu, Brenda Deyarmin, Susan Lubert, Lisa Malicki, Caroline Heckman, Richard I. Somiari, Global search for chromosomal abnormalities in infiltrating ductal carcinoma of the breast using array-comparative genomic hybridization. Cancer Genetics and Cytogenetics. ,vol. 155, pp. 108- 118 ,(2004) , 10.1016/J.CANCERGENCYTO.2004.02.023
David L Wheeler, Deanna M Church, Ron Edgar, Scott Federhen, Wolfgang Helmberg, Thomas L Madden, Joan U Pontius, Gregory D Schuler, Lynn M Schriml, Edwin Sequeira, Tugba O Suzek, Tatiana A Tatusova, Lukas Wagner, None, Database resources of the National Center for Biotechnology Information: update Nucleic Acids Research. ,vol. 32, pp. 35D- 40 ,(2004) , 10.1093/NAR/GKH073
R. Ramakrishnan, An assessment of Motorola CodeLink microarray performance for gene expression profiling applications. Nucleic Acids Research. ,vol. 30, ,(2002) , 10.1093/NAR/30.7.E30
Richard I. Somiari, Anthony Sullivan, Stephen Russell, Stella Somiari, Hai Hu, Rick Jordan, Alisha George, Richard Katenhusen, Alicja Buchowiecka, Cletus Arciero, Henry Brzeski, Jeff Hooke, Craig Shriver, High-throughput proteomic analysis of human infiltrating ductal carcinoma of the breast Proteomics. ,vol. 3, pp. 1863- 1873 ,(2003) , 10.1002/PMIC.200300560
B. Ribar, The major role of human AP-endonuclease homolog Apn2 in repair of abasic sites in Schizosaccharomyces pombe Nucleic Acids Research. ,vol. 32, pp. 115- 126 ,(2004) , 10.1093/NAR/GKH151
Cathy H Wu, Lai-Su L Yeh, Hongzhan Huang, Leslie Arminski, Jorge Castro-Alvear, Yongxing Chen, Zhangzhi Hu, Panagiotis Kourtesis, Robert S Ledley, Baris E Suzek, Cholanayakanahalli R Vinayaka, Jian Zhang, Winona C Barker, None, The Protein Information Resource Nucleic Acids Research. ,vol. 31, pp. 345- 347 ,(2003) , 10.1093/NAR/GKG040
Larry Kerschberg, Doyle J. Weishar, Conceptual Models and Architectures for Advanced Information Systems Applied Intelligence. ,vol. 13, pp. 149- 164 ,(2000) , 10.1023/A:1008340529122