Bronchial challenges and respiratory symptoms in elite swimmers and winter sport athletes: Airway hyperresponsiveness in asthma: its measurement and clinical significance.

摘要: This study was aimed at the following: (1) prevalence of airway hyperresponsiveness (AHR) and exercise-induced bronchoconstriction (EIB) in swimmers winter sport athletes according to previously recommended regulatory agencies criteria, (2) relationship between respiratory symptoms AHR/EIB, (3) impact chosen cutoff value for AHR on its prevalence, (4) effect positive eucapnic voluntary hyperpnea (EVH) test using highest vs lowest spirometric post-EVH values calculate magnitude response. We compared with responses methacholine challenge EVH 45 swimmers, athletes, 30 controls. Two cutoffs were analyzed: ≤ 4 mg/mL (the agencies' criteria AHR) 16 mg/mL. Sixty percent 29% 17% controls had evidence EIB or (with criteria). Among a provocative concentration inducing 20% decrease FEV 1 mg/mL, 43% 100% symptomatic ( P measured each time point used identify maximal response calculation response, although these prevalences higher if we value. suggests that AHR/EIB is frequent whereas frequently reported are often not related AHR/EIB. Furthermore, choice methods assessing influences EIB. Trial registration: clinicaltrials.gov; Identifier NCT 00686491 00686452.