Telomerase confers resistance to caspase-mediated apoptosis.

摘要: There is growing evidence that accelerated telomeric attrition and/or aberrant telomerase activity contributes to pathogenesis in a number of diseases. Likewise, there increasing interest develop new therapies restore or replace dysfunctional cells characterized by short length using telomerase-positive counterparts stem cells. While adds repeats de novo contributing enhanced proliferative capacity and lifespan, it may also increase cellular survival conferring resistance apoptosis. Consequently, we sought determine the involvement for reduced apoptosis ovarian surface epithelial We found expression hTERT, catalytic component telomerase, was sufficient specific reduce caspase-mediated Further, hTERT activation caspases 3, 8, 9, pro-apoptotic mitochondrial proteins t-BID, BAD, BAX increased anti-apoptotic protein, Bcl-2. The ability suppress p-jnk dependent since abrogation jnk with jip abolished these findings indicate promote suppressing jnk-dependent caspase- mediated