Auditory event-related potentials and electrodermal activity in medicated and unmedicated schizophrenics
作者： Walton T. Roth , Jayme Goodale , Adolf Pfefferbaum
DOI: 10.1016/0006-3223(91)90094-3
关键词:
摘要: Event-related potentials (ERPs) and electrodermal activity were studied in 14 medicated schizophrenics, 17 unmedicated 23 age- education-matched controls. Subjects run three auditory stimulus paradigms differing from the usual ERP having interstimulus intervals greater than 12 sec to permit measurement of longer latency skin conductance response (SCR). In every paradigm but not schizophrenics had smaller N120 amplitudes fewer SCRs addition, showed reduced P200 amplitude latency, P320 levels certain paradigms. These effects cannot easily be attributed different mental states patients, since their Brief Psychiatric Rating Scale scores almost same. It is more probable that antipsychotic antiparkinsonian drugs through anticholinergic mechanisms attenuated other biological mechanisms.
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