A magnetically actuated valve for centrifugal microfluidic applications
作者： Ziliang Cai , Jiwen Xiang , Binzhen Zhang , Wanjun Wang
DOI: 10.1016/J.SNB.2014.08.087
关键词:
摘要: Abstract A novel magnetically actuated valving system was designed, fabricated, and tested. It is very suitable for use in centrifugal microfluidic platforms. The fluidic structure of the valve fabricated by polydimethylsiloxane (PDMS) replica molding process sandwiched between two permanent magnets. working principle based on deformation PDMS micro-channel under magnetic force. flyball governor integrated platform to control distance magnets during operation. When stationary or spins at low speed, facing produce enough force overcome elastic covering membrane. membrane can therefore completely block flow channel. spinning speed increases a critical value, helps pull bottom-side magnet away, which reduces consequently opens channel valve. Therefore, controlled manipulating governor. Its burst frequency be easily tuned various load settings. actuation four valves Lab-on-CD characterized with respect mass flyball, intensity field preload supporting spring. experimental results show that ranges from 800 rpm 1600 rpm cross-section 100 μm wide × 200 μm high. This new design offers several advantages including simple fabrication, multiple use, robust control, universal application easy integration. also attains flexibility switch open state closed operation, making it capable complex fluid handling. used systems biological, chemical medical applications.
sci-hub.se 参考文章(19)
Nicole Pamme, Magnetism and microfluidics Lab on a Chip. ,vol. 6, pp. 24- 38 ,(2006) , 10.1039/B513005K
Yongqing Xi, David A. Duford, Eric D. Salin, Automated liquid-solid extraction of pyrene from soil on centrifugal microfluidic devices. Talanta. ,vol. 82, pp. 1072- 1076 ,(2010) , 10.1016/J.TALANTA.2010.06.007
Robert Gorkin III, Charles E. Nwankire, Jennifer Gaughran, Xin Zhang, Gerard G. Donohoe, Martha Rook, Richard O'Kennedy, Jens Ducrée, Centrifugo-pneumatic valving utilizing dissolvable films Lab on a Chip. ,vol. 12, pp. 2894- 2902 ,(2012) , 10.1039/C2LC20973J
Jose L. Garcia-Cordero, Dirk Kurzbuch, Fernando Benito-Lopez, Dermot Diamond, Luke P. Lee, Antonio J. Ricco, Optically addressable single-use microfluidic valves by laser printer lithography Lab on a Chip. ,vol. 10, pp. 2680- 2687 ,(2010) , 10.1039/C004980H
Chang-Yu Chen, Chang-Hung Chen, Ting-Yuan Tu, Cheng-Ming Lin, Andrew M. Wo, Electrical isolation and characteristics of permanent magnet-actuated valves for PDMS microfluidics Lab on a Chip. ,vol. 11, pp. 733- 737 ,(2011) , 10.1039/C0LC00415D
David C. Duffy, Heather L. Gillis, Joe Lin, Norman F. Sheppard, Gregory J. Kellogg, Microfabricated Centrifugal Microfluidic Systems: Characterization and Multiple Enzymatic Assays Analytical Chemistry. ,vol. 71, pp. 4669- 4678 ,(1999) , 10.1021/AC990682C
Stefan Haeberle, Norbert Schmitt, Roland Zengerle, Jens Ducrée, Centrifugo-magnetic pump for gas-to-liquid sampling Sensors and Actuators A-physical. ,vol. 135, pp. 28- 33 ,(2007) , 10.1016/J.SNA.2006.09.001
David Vokoun, Marco Beleggia, Luděk Heller, Petr Šittner, Magnetostatic interactions and forces between cylindrical permanent magnets Journal of Magnetism and Magnetic Materials. ,vol. 321, pp. 3758- 3763 ,(2009) , 10.1016/J.JMMM.2009.07.030
Jonathan Siegrist, Robert Gorkin, Liviu Clime, Emmanuel Roy, Régis Peytavi, Horacio Kido, Michel Bergeron, Teodor Veres, Marc Madou, Serial siphon valving for centrifugal microfluidic platforms Microfluidics and Nanofluidics. ,vol. 9, pp. 55- 63 ,(2010) , 10.1007/S10404-009-0523-5
Daniel Mark, Tobias Metz, Stefan Haeberle, Sascha Lutz, Jens Ducrée, Roland Zengerle, Felix von Stetten, Centrifugo-pneumatic valve for metering of highly wetting liquids on centrifugal microfluidic platforms. Lab on a Chip. ,vol. 9, pp. 3599- 3603 ,(2009) , 10.1039/B914415C