Stable igg4 based binding agent formulations
作者： Dirk Usener , Annika Hagendorf , Julia Schnieders , Ahmed Youssef , Martina Kirsch
DOI:
关键词:
摘要: The present invention provides stable pharmaceutical antibody formulations, including liquid drug product formulations and lyophilized comprising an IgG4 binding agent a citrate buffer, wherein the pH of formulation is at or below both 6 pI agent. can be used in treatment chronic bowel diseases rheumatoid arthritis.
glgoo.top参考文章(398)
Lerner Ea, How to make a hybridoma. Yale Journal of Biology and Medicine. ,vol. 54, pp. 387- 402 ,(1981)
M.R. Suresh, A.C. Cuello, C. Milstein, Bispecific monoclonal antibodies from hybrid hybridomas. Methods in Enzymology. ,vol. 121, pp. 210- 228 ,(1986) , 10.1016/0076-6879(86)21019-8
Paul Deutsch, Meng Zhang, Anti-light antibody therapy for inflammatory bowel disease ,(2013)
Yasunori Yamamoto, Hideo Yuasa, Hideaki Hagiwara, STABILIZED HUMAN MONOCLONAL CLN-IgG ANTIBODY PREPARATION ,(1992)
Pindar A, Slade Cj, Stevenson Gt, A chimeric antibody with dual Fc regions (bisFabFc) prepared by manipulations at the IgG hinge. Anti-cancer Drug Design. ,vol. 3, pp. 219- 230 ,(1989)
Nils B. Adey, Willem P.C. Stemmer, Brian K. Kay, CHAPTER 16 – Preparation of Second-Generation Phage Libraries Phage Display of Peptides and Proteins#R##N#A Laboratory Manual. pp. 277- 291 ,(1996) , 10.1016/B978-012402380-2/50018-6
James G. Rheinwald, Chapter 15 Serial Cultivation of Normal Human Epidermal Keratinocytes Methods in Cell Biology. ,vol. 21, pp. 229- 254 ,(1980) , 10.1016/S0091-679X(08)60769-4
Walter Ferlin, Subhashini Arimilli, Simonetta Mocci, Shrikant Deshpande, Methods for treating disease with antibodies to cxcr3 ,(2001)
Ruiyin Chu, David James Reczek, Method for immobilizing membrane proteins on surfaces ,(2014)
Robert E. Hawkins, Stephen J. Russell, Greg Winter, Selection of phage antibodies by binding affinity. Mimicking affinity maturation. Journal of Molecular Biology. ,vol. 226, pp. 889- 896 ,(1992) , 10.1016/0022-2836(92)90639-2