Enhanced In Vivo Growth of Lymphoma Tumors in the Absence of the NK-Activating Receptor NKp46/NCR1

摘要: The in vitro elimination of virus-infected and tumor cells by NK is regulated a balance between signals conveyed via specific inhibitory activating receptors. Whether specifically the NK-activating receptor NKp46 (NCR1 mice) are directly involved eradication vivo still largely unknown. Since NKp46/NCR1 ligands have not been identified yet, we use screening technique to identify functional for which based on cell reporter assay discover NCR1 ligand PD1.6 lymphoma line. To study whether important vivo, used Ncr1 knockout Ncr1(gfp/gfp) mice generated our group. Strikingly, all developed growing tumors, whereas initial growth was observed wild-type tumors were completely rejected as time progressed. other lines such B10 EL4 equivalent mice. Finally, show that less killed both absence NKp46/NCR1. Our results therefore reveal crucial role some cells.