Multifunctional nanocarriers for cell imaging, drug delivery, and near-IR photothermal therapy.
作者： Rui Guo , Leyang Zhang , Hanqing Qian , Rutian Li , Xiqun Jiang
DOI: 10.1021/LA903893N
关键词:
摘要: Multifunctional nanocarriers based on chitosan/gold nanorod (CS-AuNR) hybrid nanospheres have been successfully fabricated by a simple nonsolvent-aided counterion complexation method. Anticancer drug cisplatin was subsequently loaded into the obtained nanospheres, utilizing loading space provided chitosan spherical matrix. In vitro cell experiments demonstrated that CS-AuNR can not only be utilized as contrast agents for real-time imaging but also serve near-infrared (NIR) thermotherapy nanodevice to achieve irradiation-induced cancer death owing unique optical properties endowed encapsulated gold nanorods. addition, an effective attack cells anticancer has observed, rendering all-in-one system possessing delivery, imaging, and photothermal therapy functionalities.
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