Interstitial light application for photodynamic therapy in a rat brain tumor model

摘要: The usefulness of repetitive ALA mediated PDT is being evaluated in a rat brain tumor model. In preliminary experiments an optical fiber was repeatedly introduced directly into the to apply light, requiring multiple surgical procedures. attempt refine animal model, indwelling light applicator, using modified microdialysis guide cannula has been developed. fixed scull and can remain for several weeks without complications. studies need repeated mounting stereotactic frame procedures be eliminated. applicator also makes it feasible employ low fluence rates with long treatment times, which correspond future clinically relevant protocols. rate distribution measured vivo compared diffusion theory Monte Carlo simulations estimate tissue properties at 632 nm. modeling suggested reduced scattering coefficient 38 cm -1 , absorption 0.46 penetration depth 0.14 cm.