Influence of light fluence rate on the effects of photodynamic therapy in an orthotopic rat glioma model.
作者： Even Angell-Petersen , Signe Spetalen , Steen J. Madsen , Chung-Ho Sun , Qian Peng
DOI: 10.3171/JNS.2006.104.1.109
关键词:
摘要: Object Failure of treatment for high-grade gliomas is usually due to local recurrence at the site resection, indicating that a more aggressive therapy could be beneficial. Photodynamic (PDT) involving administration tumor-localizing photosensitizing drug, in this case aminolevulinic acid (ALA). The effect depends on total light energy delivered target tissue, but may also influenced by rate delivery. Methods In vitro experiments showed sensitivity ALA PDT BT4C multicellular tumor spheroids depended delivery (fluence rate). tumors were established intracranially BD-IX rats. Microfluorometry frozen tissue sections photosensitization produced with better than 200:1 tumor/normal selectivity after injection. Four hours intraperitoneal injection (125 mg/kg), 26 J 632 nm was interstitially over 15 (high fluence rate) or 90 (low fluence...
utsystem.edu参考文章(42)
Kent E. Wallner, Joseph H. Galicich, George Krol, Ehud Arbit, Mark G. Malkin, Patterns of Failure Following Treatment for Glioblastoma Multiforme and Anaplastic Astrocytoma International Journal of Radiation Oncology Biology Physics. ,vol. 16, pp. 1405- 1409 ,(1989) , 10.1016/0360-3016(89)90941-3
Ying Jt. Diana Walstad, J. Tony Brown, Stephen K. Powers, IMPROVED SURVIVAL FROM INTRACAVITARY PHOTODYNAMIC THERAPY OF RAT GLIOMA Photochemistry and Photobiology. ,vol. 56, pp. 385- 390 ,(1992) , 10.1111/J.1751-1097.1992.TB02175.X
Even Angell-Petersen, Dag R. Sorensen, Steen J. Madsen, Henry Hirschberg, Interstitial light application for photodynamic therapy in a rat brain tumor model Biomedical optics. ,vol. 5312, pp. 415- 423 ,(2004) , 10.1117/12.527417
Willem M Star, Light dosimetry in vivo Physics in Medicine and Biology. ,vol. 42, pp. 763- 787 ,(1997) , 10.1088/0031-9155/42/5/003
John Webber, Yu Luo, Richard Crilly, David Fromm, David Kessel, An apoptotic response to photodynamic therapy with endogenous protoporphyrin in vivo. Journal of Photochemistry and Photobiology B-biology. ,vol. 35, pp. 209- 211 ,(1996) , 10.1016/S1011-1344(96)07291-0
Walter Stummer, Susanne Stocker, Alexander Novotny, Axel Heimann, Oliver Sauer, Oliver Kempski, Nikolaus Plesnila, Joachim Wietzorrek, H.J. Reulen, In vitro and in vivo porphyrin accumulation by C6 glioma cells after exposure to 5-aminolevulinic acid. Journal of Photochemistry and Photobiology B-biology. ,vol. 45, pp. 160- 169 ,(1998) , 10.1016/S1011-1344(98)00176-6
S. Ito, W. Rachinger, H. Stepp, H. J. Reulen, W. Stummer, Oedema formation in experimental photo-irradiation therapy of brain tumours using 5-ALA. Acta Neurochirurgica. ,vol. 147, pp. 57- 65 ,(2005) , 10.1007/S00701-004-0422-1
Qian Peng, Trond Warloe, Kristian Berg, Johan Moan, Magne Kongshaug, Karl-Erik Giercksky, Jahn M. Nesland, 5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges. Cancer. ,vol. 79, pp. 2282- 2308 ,(1997) , 10.1002/(SICI)1097-0142(19970615)79:12<2282::AID-CNCR2>3.0.CO;2-O
Olav Engebraaten, Geir Olav Hjortland, Henry Hirschberg, Øystein Fodstad, Growth of precultured human glioma specimens in nude rat brain. Journal of Neurosurgery. ,vol. 90, pp. 125- 132 ,(1999) , 10.3171/JNS.1999.90.1.0125
Man-Kai Cheng, John McKean, Donald Boisvert, John Tulip, Photoradiation therapy: current status and applications in the treatment of brain tumors. Surgical Neurology. ,vol. 25, pp. 423- 435 ,(1986) , 10.1016/0090-3019(86)90080-7