Gender and brain regions specific differences in brain derived neurotrophic factor protein levels of depressed individuals who died through suicide.

摘要: Considerable evidence supports the view that depressive illness and suicidal behaviour stem from perturbations of neuroplasticity. Presently, we assessed whether depressed individuals who died by suicide displayed brain region-specific changes in derived neurotrophic factor (BDNF) such effects varied gender. Using postmortem samples non-psychiatric controls suicide, BDNF protein levels were within hippocampus frontopolar prefrontal cortex using Western blot. As expected, reduced among female suicides; however, males showed no effect. Contrastingly, hippocampus, male but not suicides significant reductions levels. Although mechanisms driving gender region specific are unclear, our data do support notion complex alterations neuroplasticity may be fundamentally involved illness.