Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders.

摘要: Background: Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor (trkB-TK+) and glutamic acid decarboxylase (GAD67) mRNA levels have previously been found to be reduced in the prefrontal cortex of patients with schizophrenia. To determine whether this reduction extends other brain regions, we measured expression BDNF, trkB-TK+ GAD67 regions hippocampus, including dentate gyrus (DG), cornu ammonis subfields (CA1‐4), subiculum entorhinal (EC) individuals schizophrenia, bipolar disorder, major depression unaffected controls. Methods: In situ hybridization was performed on postmortem tissue obtained from Stanley Foundation Consortium analyzed using film-based quantification. Results: Analyses covariance comparing among all groups revealed a significant decrease BDNF CA4 bi polar disorder group compared controls (33%). We significantly schizophrenia (36%) layer II EC (28%, 21%, respectively) addition, were both DG (23%) (60%) Individuals also expressed less (44%) hippocampus. Limitations: It is necessary account for factors that influence molecular preservation tissue, pH, interval storage time. Moreover, there are limitations sensitivity method Conclusion: Our findings show abnormal hippocampus individ uals mood disorders, indicating fundamental properties hippocampal signalling transmission, plasticity circuitry may affected these mental illnesses.