Nuclear relaxation studies in ligand-macromolecule affinity index determinations
作者： Claudio Rossi , Alessandro Donati , Claudia Bonechi , Gianfranco Corbini , Roberto Rappuoli
DOI: 10.1016/S0009-2614(96)01296-1
关键词:
摘要: Abstract An ‘affinity index’, representing the global affinity between a ligand and biomacromolecular receptor, is proposed. It determined as slope of linear relations ΔR1SE receptor concentration has advantage providing measure ligand-biomacromolecule which independent number interaction sites. The method was applied to calculation lamotrigine-albumin index.
harvard.edu
elsevier.com
sci-hub.se 参考文章(16)
Kurt Wuthrich, NMR of proteins and nucleic acids ,(1986)
G.Naray Naray-Szabo, Steric Aspects Of Biomolecular Interactions ,(1987)
Elena Gaggelli, Gianni Valensin, Tamir Kushnir, Gil Navon, Determination of absolute values of dipolar cross‐relaxation rates for ligands bound to macromolecules using double‐selective T1 Magnetic Resonance in Chemistry. ,vol. 30, pp. 461- 465 ,(1992) , 10.1002/MRC.1260300602
Claudio Rossi, Alessandro Donati, Maria Rosaria Sansoni, Nuclear magnetic resonance as a tool for the identification of specific DNA—ligand interaction Chemical Physics Letters. ,vol. 189, pp. 278- 280 ,(1992) , 10.1016/0009-2614(92)85139-2
Gianni Valensin, Tamar Kushnir, Gil Navon, Selective and nonselective proton spin-lattice relaxation studies of enzyme-substrate interactions Journal of Magnetic Resonance. ,vol. 46, pp. 23- 29 ,(1982) , 10.1016/0022-2364(82)90159-7
Martina Bebin, Thomas P. Bleck, New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol. Drugs. ,vol. 48, pp. 153- 171 ,(1994) , 10.2165/00003495-199448020-00003
R. Kaptein, R. Boelens, R. M. Scheek, W. F. Van Gunsteren, Protein structures from NMR. Biochemistry. ,vol. 27, pp. 5389- 5395 ,(1988) , 10.1021/BI00415A001
I.D Campbell, Ray Freeman, Influence of cross-relaxation on NMR spin-lattice relaxation times Journal of Magnetic Resonance. ,vol. 11, pp. 143- 162 ,(1973) , 10.1016/0022-2364(73)90002-4
George Scatchard, The Attractions of Proteins for Small Molecules and Ions Annals of the New York Academy of Sciences. ,vol. 51, pp. 660- 672 ,(1949) , 10.1111/J.1749-6632.1949.TB27297.X
Neri Niccolai, Maria P. Miles, William A. Gibbons, Internal motions studies of an angiotensin pentapeptide using proton relaxation parameters. Biochemical and Biophysical Research Communications. ,vol. 91, pp. 157- 163 ,(1979) , 10.1016/0006-291X(79)90597-7