The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases.

摘要: The grade of a tumour is gauged on the subjective assessment number histopathological parameters. problems associated with this exercise were viewed from historical perspective and survival analysis 447 patients receiving surgery for rectal adenocarcinoma was undertaken. Only deaths included as events in analysis. Seven grade-related parameters scored by one observer. A grading system constructed using Cox regression model. variables best-fitting parsimonious model comprised lymphocytic infiltration, tubule configuration pattern growth. Scores derived four created which groups similar size. Good reproducibility selected demonstrated. Grade-related then allowed to compete stage-related an overall pathological prognostic categories. best affected lymph nodes, presence infiltration extent spread through bowel wall. set five categories developed