The macrosphere model—an embolic stroke model for studying the pathophysiology of focal cerebral ischemia in a translational approach

摘要: The main challenge of stroke research is to translate promising experimental findings from the bench bedside. Many suggestions have been made how achieve this goal, identifying need for appropriate animal models as one key issue. We here discuss macrosphere model focal cerebral ischemia in rat, which closely resembles pathophysiology human both its acute and chronic phase. Key pathophysiological processes such brain edema, cortical spreading depolarizations (CSD), neuroinflammation, stem cell-mediated regeneration are observed model, following characteristic temporo-spatial patterns. Non-invasive vivo imaging allows studying very onset up late remodeling an intraindividual longitudinal fashion. Such a design pre-clinical studies provides basis successful translation into clinic.