PRIMARY IMMUNODEFICIENCIES: Report of a World Health Organization Committee

摘要: 1. Two registries are to be established in association with WHO, the object of gathering and recording information on cases immunodeficiency from all over world. One registry will comprise primary that have received transplants any immunologically competent organ, cell, or cell product, e.g., bone marrow, thymus, transfer factor. It organized by W. Hitzig M. Seligmann. The other malignant tumour found patients immunodeficiency; it R. A. Good, who also arrange for pathological material submitted study selected pathologists. organizers collate periodically report both registries. 2. Standardization diagnostic procedures additional studies related tests required. a. There is a need standard preparations antigens assessing antibody formation as described. A sufficiently large batch such should prepared, aliquots sent, request, use clinicians investigating immunodeficiency. b. Methods measuring serum antibodies standardized, vitro measurement cell-mediated immunity, cytotoxicity macrophage migration inhibition factors, further developed. 3. Therapeutic standardized assessed. Aggregates immunoglobulin intramuscular intravenous injection looked those recommended. National agencies responsible production develop stable aggregate-free intact IgG, without fragments relatively normal vivo survival, treatment c. would value determine relative effectiveness therapy plasma. Clinical trials might designed this purpose. d. Immunoglobulin having high contents specific would, if available, valuable infections. e. Further research required new methods destroying biological activity lymphocytes whole blood. f. Pools immunoglobulin, prepared Cohn FII donors absence genetic allotype, may anti-allotype antibodies.