Long-chain polyunsaturated fatty acids, pregnancy, and pregnancy outcome.

摘要: During pregnancy, essential long-chain polyunsaturated fatty acids (LCPUFAs) play important roles as precursors of prostaglandins and structural elements cell membranes. Throughout gestation, accretion maternal, placental, fetal tissue occurs consequently the LCPUFA requirements pregnant women their developing fetuses are high. This is particularly true for docosahexaenoic acid (DHA; 22:6n-3). The ratio DHA to its status marker, docosapentaenoic (22:5n-6), in maternal plasma phospholipids decreases significantly during pregnancy. suggests that pregnancy associated with difficulty coping high demand DHA. newborn multiplets lower than singletons; same infants multigravidas compared those primigravidas preterm term neonates. Because at birth seems have a long-term effect, fetus should receive an adequate supply LCPUFAs. Data from international comparative study indicated that, especially n-3 LCPUFAs, dependent on intake; supplementation precursors, or both increased concentrations umbilical phospholipids. However, significant competition between 2 families was observed, which implies effective requires mixture n-6 acids. Further research needed determine whether higher phospholipid will functional benefits mothers children.