A combination treatment strategy using pyrantel pamoate and oxibendazole demonstrates additive effects for controlling equine cyathostomins

摘要: Summary Anthelmintics of the avermectin/milbemycin class continue to demonstrate highest efficacy against cyathostomin nematodes; however, over-reliance on these drugs is increasing likelihood that recent emerging resistance will worsen. Use benzimidazole and pyrantel compounds given concurrently may provide sufficiently high serve as a viable treatment alternative drugs, thus reducing selective pressures for development. The study was conducted determine if oxibendazole (OBZ) pamoate (PYR) would have greater when used in combination vs. what either drug could achieve individually, protocol consistently faecal egg count reduction (FECR) rates >90%, general threshold acceptable efficacy. Horses various ages breeds 11 horse farms were assigned randomly with OBZ (n = 34), PYR 35), or both 61). A performed each prior 9–14 days post treatment. Mean FECR percentages calculated group individual farms, across all farms. Combination achieved >90% mean >95% 9 Overall arithmetic 90.03%, 81.10% 96.35% horses treated respectively OBZ, PYR, 2 combination. demonstrated an additive effect whereby anthelmintics had significantly than alone. can be efficacious choice controlling cyathostomins, thereby drugs.