A reevaluation of new histone deposition on replicating chromatin.
作者： V. Jackson , R. Chalkley
DOI: 10.1016/S0021-9258(19)69371-3
关键词:
摘要: In this study, we have density-labeled newly replicated DNA in hepatoma tissue culture cells and separated the nucleoprotein from bulk material using density gradient centrifugation. These experiments indicate that only synthesized histones H3 H4 deposit specifically on DNA. Histones H2A H2B show a partial preference histone H1 shows no for deposition new also whole cell cycle, non-H1 remain associated with same upon which they were initially deposited. However, when region is during next distribute equally to both daughter strands. An increase or decrease level of modification (acetylation) induced by sodium butyrate treatment does not alter vivo stability histone-DNA interactions. Experiments involved labeling SV40 minichromosomes [3H]lysine confirm our observations are selectively depend
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