1,2-Dihydroisoquinolines

摘要: Publisher Summary It is the purpose of this chapter to summarize knowledge chemistry 1,2-dihydroisoquinolines and evaluate those reactions that may be interpreted in terms enamine character. The begins with discussion formation through various methods namely, reduction (where isoquinolinium salts are reduced 2-alkyl- 1,2-dihydroisoquinoline derivatives by sodium dithionite, lithium aluminum hydride (LAH), or dialkyl hydrides) — other nucleophilic additions c-1 cyclization benzylaminoacetaldehyde acetals (one most useful for generating involves treating a acetal 6 n hydrochloric acid); miscellaneous ways. stability 1 ,2-dihydroisoquinolines discussed considered unstable difficult isolate pure state. then turns detection estimation ,2-dihydroisoquinolines. can detected red coloration develops when they exposed air mineral acids, also way reduce silver nitrate solution UV spectral measurement. qualitative absorption curve contains medium intensity broad band at 330–340 nm (in ethanol) which extremely structures. Finally, has detail about oxidation, reduction, hydroboration, reactions, rearrangements, 1,2-dihydroisoquinolinesin biosynthesis.