Dad’s Snoring May Have Left Molecular Scars in Your DNA: the Emerging Role of Epigenetics in Sleep Disorders

摘要: The sleep-wake cycle is a biological phenomena under the orchestration of neurophysiological, neurochemical, neuroanatomical, and genetical mechanisms. Moreover, homeostatic circadian processes participate in regulation sleep across light-dark period. Further complexity understanding genesis engages disturbances which have been characterized classified variety disorders. most prominent alterations include insomnia as well excessive daytime sleepiness. On other side, several human diseases linked with direct changes DNA, such chromatin configuration, genomic imprinting, DNA methylation, histone modifications (acetylation, ubiquitylation or sumoylation, etc.), activating RNA molecules that are transcribed from but not translated into proteins. Epigenetic theories primarily emphasize interaction between environment gene expression. According to these approaches, mammals exposed has significant role determining epigenetic occurring chromosomes ultimately would influence only development also descendants' physiology behavior. Thus, what makes epigenetics intriguing that, unlike genetic variation, altered directly by and, some cases, may be inherited future generations. it likely might contribute and/or control possibly, an undescribed link An exciting new horizon research arising since represents relevance study how genome learns its experiences modulates behavior, including sleep.