Direct cellular reprogramming for cardiac repair and regeneration

摘要: Heart failure is a major cause of morbidity and mortality, characterized by depletion functioning cardiomyocytes, myocardial remodelling, impaired contractile function. As the heart has limited capacity for repair, current treatments do not reverse attrition, novel regenerative strategies are imperative. Although cell delivery-based approaches remain promising, in situ reprogramming endogenous cardiac fibroblasts (which pathophysiologically implicated remodelling) into functional cardiomyocytes may represent an advantageous approach. Several groups report successful vitro vivo murine fibroblasts, using critical transcription factors, microRNA mimics, small molecules, to cells demonstrating cardiomyocyte-like morphology, gene expression, spontaneous contraction, which improve function post-infarct models. proof-of-concept studies demonstrate human significant barriers therapeutic remain. In this review, we evaluate status explore future perspectives within context clinical translation.