Adipose tissue sensitivity to radiation exposure.

摘要: Treatment of cancer using radiation can be significantly compromised by the development severe acute and late damage to normal tissue. Treatments that either reduce risk severity or facilitate healing injuries are being developed, including autologous adipose tissue grafts repair defects involutional disorders result from tumor resection. Adipose is specialized in energy storage contains different cell types, preadipocytes, which could used for transplantation. It has long been considered a poorly proliferative connective tissue; however, effects ionizing on have not investigated. Therefore, aim this study was characterize alterations induced total body irradiation. A decrease proliferating cells, as well significant increase apoptotic observed vivo inguinal fat pads following Additionally, irradiation altered hematopoietic population. Decreases proliferation differentiation capacities non-hematopoietic progenitors were also Together, these data demonstrate subcutaneous very sensitive irradiation, leading profound alteration its developmental potential. This alter reconstructive properties and, therefore, calls into question use transfer radiotherapy.