Long-term outcome in patients with Guillain–Barré syndrome requiring mechanical ventilation

摘要: We aimed to determine long-term disability and quality of life in patients with Guillain–Barre syndrome (GBS) who required mechanical ventilation (MV) the acute phase. Our retrospective cohort study included 110 GBS admitted an intensive care unit requiring MV (01/1999–08/2010) nine German tertiary academic medical centers. Outcome was determined 1 year or longer after hospital admission using scale, Barthel index (BI), EuroQuol-5D (EQ-5D) Fatigue Severity Scale. Linear/multivariate regression analysis used analyze predicting factors for outcome. Mean time follow up 52.6 months. Hospital mortality 5.5 % 13.6 %. Overall 53.8 had a favorable outcome (GBS score 0–1) 73.7 survivors no mild (BI 90–100). In five dimensions EQ-5D “mobility”, “self-care”, “usual activities”, “pain” “anxiety/depression” impairments were stated by 50.6, 58.4, 36.4, 36.4 50.6 patients, respectively. A severe fatigue present 30.4 patients. statistically significantly correlated age, type therapy number immunoglobulin courses. GBS-patients phase in-hospital, are lower than that previous studies, while is compromised large fraction foremost immobility chronic pain. Efforts towards improved treatment approaches should address autonomic dysfunction further reduce rehabilitation concepts might ameliorate disability.