Light Scattering and NMR Studies of the Self-Association of the Amphiphilic Molecule Propranolol Hydrochloride in Aqueous Electrolyte Solutions
作者： Juan M. Ruso , David Attwood , Carlos Rey , Pablo Taboada , Víctor Mosquera
DOI: 10.1021/JP983900Z
关键词:
摘要: Critical concentrations, aggregation numbers, and effective micellar charges of the amphiphilic drug propranolol hydrochloride have been determined from static light scattering measurements at 25 °C in presence added electrolyte (0.0−0.5 mol kg-1 NaCl). Photon correlation spectroscopy (dynamic scattering) has shown an increase size with concentration. To quantify interaction between aggregates, data interpreted by DLVO theory. Micellar properties application mass action theory to concentration dependence 1H NMR chemical shifts confirming results obtained scattering.
acs.org
manchester.ac.uk参考文章(30)
Mario Corti, Vittorio Degiorgio, Quasi-elastic light scattering study of intermicellar interactions in aqueous sodium dodecyl sulfate solutions The Journal of Physical Chemistry. ,vol. 85, pp. 711- 717 ,(1981) , 10.1021/J150606A021
Claudio Minero, Edmondo Pramauro, Ezio Pelizzetti, Vittorio Degiorgio, Mario Corti, Micellar properties of sodium dodecylpoly(oxyethylene) sulfates The Journal of Physical Chemistry. ,vol. 90, pp. 1620- 1625 ,(1986) , 10.1021/J100399A033
David Attwood, Self-association of phenothiazine drugs in aqueous solutions of high ionic strength Journal of the Chemical Society, Faraday Transactions. ,vol. 79, pp. 2669- 2677 ,(1983) , 10.1039/F19837902669
Jacob N. Israelachvili, Gayle E. Adams, Measurement of forces between two mica surfaces in aqueous electrolyte solutions in the range 0–100 nm Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases. ,vol. 74, pp. 975- 1001 ,(1978) , 10.1039/F19787400975
D Attwood, P Fletcher, Total intensity and quasielastic light scattering studies on the association of amphiphilic drugs in aqueous electrolyte solutions Journal of Colloid and Interface Science. ,vol. 115, pp. 104- 109 ,(1987) , 10.1016/0021-9797(87)90013-0
F. Sarmiento, J. M. del Rio, G. Prieto, D. Attwood, M. N. Jones, V. Mosquera, Thermodynamics of Micelle Formation of Chlorhexidine Digluconate The Journal of Physical Chemistry. ,vol. 99, pp. 17628- 17631 ,(1995) , 10.1021/J100049A024
Bert O. Persson, Torbjorn Drakenberg, Bjorn Lindman, Amphiphile aggregation number and conformation from carbon-13 nuclear magnetic resonance chemical shifts The Journal of Physical Chemistry. ,vol. 80, pp. 2124- 2125 ,(1976) , 10.1021/J100560A014
David Attwood, Victor Mosquera, Laura Novas, Felix Sarmiento, Micellization in binary mixtures of amphiphilic drugs Journal of Colloid and Interface Science. ,vol. 179, pp. 478- 481 ,(1996) , 10.1006/JCIS.1996.0240
Jacob N. Israelachvili, D. John Mitchell, Barry W. Ninham, Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers Journal of the Chemical Society, Faraday Transactions. ,vol. 72, pp. 1525- 1568 ,(1976) , 10.1039/F29767201525
David Attwood, Roger Waigh, Ross Blundell, Debra Bloor, André Thévand, Elizabeth Boitard, Jean-Paul Dubès, Henri Tachoire, 1H and13C NMR studies of the self-association of chlorpromazine hydrochloride in aqueous solution Magnetic Resonance in Chemistry. ,vol. 32, pp. 468- 472 ,(1994) , 10.1002/MRC.1260320807