Strategies for neural control of prosthetic limbs: from electrode interfacing to 3D printing.

摘要: Limb amputation is a major cause of disability in our community, for which motorised prosthetic devices offer return to function and independence. With the commercialisation increasing availability advanced technologies, there consumer need clinical drive intuitive user control. In this context, rapid additive fabrication/prototyping capacities biofabrication protocols embrace highly-personalised medicine doctrine that marries specific patient biology anatomy high-end design, manufacture functionality. Commercially-available models utilise surface electrodes are limited by their disconnect between mind device. As such, alternative strategies mind–prosthetic interfacing have been explored purposefully limb. This review investigates machine strategies, with focus on biological challenges long-term harnessing user’s cerebral commands actuation/movement electronic prostheses. It covers limitations skin, peripheral nerve brain electrodes, particular minimising foreign-body response, as well new strategy grafting muscle onto residual nerves. conjunction, also applicability tissue engineering at nerve-electrode boundary, has led pioneering work neural regeneration bioelectrode development applications neuroprosthetic interface.