A review of the preclinical and clinical evidence for protein kinase C as a target for drug development for bipolar disorder
作者： Nancy DiazGranados , Carlos A. Zarate
DOI: 10.1007/S11920-008-0081-7
关键词:
摘要: In this article, we review preclinical studies investigating the role of protein kinase C (PKC) as it pertains to mania and effective antimanic agents. We then discuss clinical conducted with tamoxifen, a relatively selective PKC inhibitor, in acute bipolar mania. conclude that is an important target-arguably first mechanistically distinct drug target for disorder. holds considerable promise novel developing new line treatments
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sci-hub.se 参考文章(31)
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