Monocytes and Macrophages in Transplantation

摘要: Phagocytosis of endogenous or exogenous particles is one the functions monocytes tissue macrophages, which effectively sequesters these antigens from immune system alternatively, presents as processed proteins to T-cells. These phagocytic mononuclear cells express a large variety surface molecules allowing them recognize infectious and ligands prior engulfment, inducing intracellular signaling, altering their biosynthesis secretion. The term “pattern recognition receptors” has been proposed for numerous receptors, are key players in innate immunity, responsible nonself by cells.