Ornithine α-Ketoglutarate and Glutamine Supplementation During Refeeding of Food-Deprived Rats
作者： Frédéric Ziegler , Colette Coudray-Lucas , Alain Jardel , Elisabeth Lasnier , Jacques Le Boucher
DOI: 10.1177/0148607192016006505
关键词:
摘要: The aim of this study was to compare the efficiency ornithine alpha-ketoglutarate (OKG) and glutamine supplementation in an experimental model denutrition that provides well-characterized disturbances amino acid patterns. Male Wistar rats (187 +/- 11 g; five each group) were starved for 3 days then refed 7 with oral diet (192 kcal kg-1.day-1 2.25 g nitrogen kg-1.day-1), supplemented 0.19 form OKG, glutamine, or casein (control group). Food deprivation induced a fall most tissue acids, notable exception muscle leucine liver glutamate, which increased by 43% (p < .01), 11% .05), respectively. main effect OKG seen viscera, normalization pools (including proline branched-chain acids) small bowel liver. observed muscle, pools. We conclude that, doses used, act different target tissues, ie, splanchnic areas
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