Inhibited amino acid uptake in skeletal muscle during starvation.
作者： Brad W. Warner , Robert P. Hummel , Per-Olof Hasselgren , J. Howard James , Josef E. Fischer
DOI: 10.1177/0148607189013004344
关键词:
摘要: Amino acid uptake in skeletal muscle is reduced during different catabolic conditions such as sepsis, endotoxic shock, and uremia. The present study was designed to determine the effect of another condition, starvation, on amino transport muscle. Male Sprague-Dawley rats (40-60 g) were starved for 24, 48, or 72 hr soleus (SOL) muscles removed intact incubated 2 a medium consisting Krebs-Henseleit bicarbonate buffer (pH 7.4) with glucose (5 mM), [14C]-inulin, [3H]-alpha-aminoisobutyric (AIB). determined from intracellular extracellular ratio AIB following incubation. significantly after 24 starvation remained low further fasting. After distribution approximately 50% initial value. returned normal within refeeding animals that had been hr. Plasma (0.25 ml) rats, added incubation (2.75 nonfasted inhibited uptake. results suggest progressively an may be mediated by circulating factor(s) blood.
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